Effect of Lysophosphatidic Acid and Sphingosine-1-Phosphate in Neuronal Stem Cells.

Grant number: 454723 | Funding period: 2007 - 2010

Completed

Abstract

Stem cells have the potential to give rise to a vast array of differentiated cells. Neuronal stem cells (NSC) can differentiate into progenitor cells which can themselves differentiate into cells of the nervous system: neurons and macroglial cells (astrocytes, oligodendrocytes, Schwann cells). This in turn can assist in the treatment of degenerative diseases such as multiple sclerosis, Parkinson's disease, motoneuron desease etc. Our project aims to study the effects on NSC and their progenitor cells of the lysophospholipids lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), bioactive molecules known to play an essential role in the nervous system during development and inflammat..

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Related publications (10)

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Sphingosine-1-Phosphate Methods and Protocols

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This fully updated edition explores methods involving sphingosine-1-phosphate (S1P), a bioactive lysophospholipid which has become..

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Study of gap junctions in human embryonic stem cells

A Pébay, RCB Wong

2014-01-01

Gap junctional intercellular communication (GJIC) has been described in different cell types including stem cells and has been inv..

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Blockage of lysophosphatidic acid signaling improves spinal cord injury outcomes

Y Goldshmit, R Matteo, T Sztal, F Ellett, F Frisca, K Moreno, D Crombie, GJ Lieschke, PD Currie, RA Sabbadini, A Pébay

2012-09-01

Evidence suggests a proinflammatory role of lysophosphatidic acid (LPA) in various pathologic abnormalities, including in the cent..

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Modulation of LPA receptor expression in the human brain following neurotrauma

T Frugier, D Crombie, A Conquest, F Tjhong, C Taylor, T Kulkarni, C McLean, A Pébay

2011-05-01

Lysophosphatidic acid (LPA) is involved in physiological and pathological states, including in neural development and inflammation..

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LPA receptor expression in the central nervous system in health and following injury

Y Goldshmit, K Munro, SY Leong, A Pébay, AM Turnley

2010-01-01

Lysophosphatidic acid (LPA) is released from platelets following injury and also plays a role in neural development but little is ..

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Study of Gap Junctions in Human Embryonic Stem Cells

Raymond CB Wong, Alice Pebay

2010-01-01

Gap junctional intercellular communication (GJIC) has been described in different cell types including stem cells and has been inv..

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Regulation of stem cell pluripotency and neural differentiation by lysophospholipids

SM Pitson, A Pébay

2009-09-01

Lysophospholipids are bioactive signalling molecules able to act through the binding of their specific G-protein-coupled receptors..

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Role of gap junctions in embryonic and somatic stem cells

RCB Wong, MF Pera, A Pébay

2008-12-01

Stem cells provide an invaluable tool to develop cell replacement therapies for a range of serious disorders caused by cell damage..

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Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells

M Dottori, J Leung, AM Turnley, A Pébay

2008-05-01

Lysophospholipids are signaling molecules that play broad and major roles within the nervous system during both early development ..

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Stem cell regulation by lysophospholipids

A Pébay, CS Bonder, SM Pitson

2007-11-01

Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) regulate a diverse range of mammalian cell processes, largely throug..

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